My Journey with Testosterone for Anxiety

My Journey with Testosterone for Anxiety

2017-01-26 | 2 Comments

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  • You probably don’t know this about me, but for years I have been self-medicating with testosterone as a way of controlling my cortisol and hence my anxiety and stress levels.

    How does this work? Testosterone is antagonistic to cortisol. What this means is that as testosterone increases, so cortisol levels are ‘forced’ downward. Not to a point of compromised physiology, but to a point where elevated cortisol and the unpleasant symptoms associated with it are suppressed. So for example, no more restless days (or nights) where you can feel your heart beating harder (not necessarily much faster, but harder, i.e. more ‘inotropic’) and your chest feels a little bit tighter as a result. No more falling out with good friends because you over-react and behave emotionally. No more tendency to break down muscle tissue and turn it into unwanted blood glucose, leading to central obesity and metabolic syndrome. No more cortisol-induced hardening of the arteries.

    At least, that’s what I’ve noticed (in terms of satellite benefits) and to be honest I kind of lost sight of the primary reason (anxiety) until I recently let my testosterone drop too low and had to suffer 2 days (only 2 days - how do people deal with this for protracted periods? I used to know, because I was one of them, but not any more) of a hard-clenching heart, mild feelings of anxiety, stress and compromised sleep. It rocked me a little to be honest, because I’ve spent the last 15 years in a blissfully calm state of mind, brought about by intelligent hormonal control.

    Summary: I elected to create a false state of hormonal homeostasis many years ago and my recent unwanted foray into ‘normalcy’ reminded me very sharply, why I do what I do.

    Do you have an experience to share?


    2 User Comments

    • Jens


      I’ve battled with anxiety almost my whole life and tried many things to calm up down, often and as a first choice, before I really started to understand what was happening, alcohol.
      I’m wondering if you still use the Testosterone? Have you decided to find out what is causing your anxiety (biochemically)? Even if it really is low Testosterone, why is it that low?

      Posted on Oct 22, 2017 Reply
    • Kester

      I’m attempting the same thing with SARMs and haven’t noticed very much difference tbh - altho I forget to take them a lot.

      Are you using SARMs or injectables?

      If you use it for basically self-medication for anxiety/ depression, do you use a very low and continuous dosage? of which one?

      I had some oxandralone before - which is sometimes prescribed for burns patients, so I’m confident it’s very safe, altho I don’t have a prescription. The first thing I noticed on that was just that I felt less depressed than usual and slept better. What a relief!

      I have a psychopharmacology postdoc friend who told me that they know that androgens could be useful for some mechanisms underlying depressive disorders but they don’t dare use or develop treatments based on the androgenic system because the inevitable tiny proportion of patients with negative side-effects the tabloid headlines would be predictably sensational. Even tho SSRIs have really bad side-effects. ‘Irrationality thy name is human.’

      Posted on Jan 24, 2018 Reply

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