The Effects of Long-Term Nootropic Use

The Effects of Long-Term Nootropic Use

2018-11-03 | 9 Comments

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  • Some users of nootropics seem to feel that like most other supplements, these ‘brain boosters’ should be cycled (periods of use interspersed with regular ‘off’ periods) in order to maintain their long-term effectiveness.

    However this author disagrees with that philosophy, and I shall explain why.

    Shouldn’t certain supplements be cycled?

    Certainly, there are supplements that should be cycled and some of these may fall under the general category of ‘nootropic’, however they are those supplements that contain stimulant properties (and as such are not genuine ‘nootropics’ in my opinion, since they will boost catecholamine levels, thus blunting neuronal activity in the hippocampus – see related article on Ritalin, etc).

    Stimulant–containing supplements, with ingredients such as sulbutiamine, tyrosine, caffeine, etc, need to be cycled in order to prevent tolerance and a reliance on ever-increasing dosages to elicit the same level of physiological response.

    Genuine nootropic substances, such as Neurostim and Neurochill, should not need to be cycled (unless cost is a limiting factor) and indeed confer significant benefit from being used continuously for long periods of time. The reason for this is a neurophysiological phenomenon known as neuroplasticity.

    What is Neuroplasticity?

    Neuroplasticity refers to the ability of the nervous system to adapt continuously over time, in response to the environmental and behavioural stresses placed upon it. It is the reason why certain individuals who receive massive trauma to the brain may recover almost completely, even when half of the brain has been surgically removed.

    It is the reason why you can find yourself becoming more and more adept at a specific mental task, or series of challenges. Do you remember back in time before we all had mobile telephones? I bet you were quite good at memorising telephone numbers. I know I was. Now that we no longer ‘train’ our brains to memorise long strings of numbers, most of us have ‘lost’ that ability. That is neuroplasticity at work. We don’t keep abilities that we don’t regularly practice.

    And so it is with learning. The more we force ourselves to study, the better the brain becomes at learning new information.

    Long Term Nootropic Effects

    For the nootropics user, the effects of long-term nootropic use can be almost god-like in their cumulative effect. You see nootropics facilitate learning and recall. This causes you to become ‘good’ at learning and as most of use appreciate, the ‘better’ you are at something, the more you tend to do it, which creates a positive feedback loop.

    BUT, on the cellular and sub-cellular level, certain nootropics can directly facilitate synaptogenesis – the formation of neural pathways and connections within the CNS. This is a directly accelerated form of neuroplasticity. Synaptogenesis occurs naturally and is thought to be almost entirely responsible for the learning of new skills and the reinforcement of existing skills and memories.

    So the longer we take nootropics for, the more we encourage neuroplasticity, which creates new learning abilities, which means that for a given amount of study, we ‘learn’ faster, resulting in more accelerated learning, which creates greater levels of neuroplasticity, (further facilitated by nootropics) which creates even faster learning ability, which fosters greater neuroplacticity… and so it goes on.

    Now it would be foolish to assume we could keep accelerating our learning infinitely, but having experimented with this phenomenon personally, by taking Neurostim almost continuously for over 3 years, I can vouch for the fact that the end result (in my case – further nootravelling is entirely possibly, I suspect) can be a totally surprising and impressive experience.

    I once wrote an article about this and I called it ‘unconscious learning’ because I was no longer consciously studying all my material, but rather seemed to pick it up by a process of ‘cognitive osmosis’. Simply being around the top students in my class whilst they discussed and learned themselves, seemed to confer their knowledge into my cortex. I knew things that I didn’t even know I knew. People would ask questions and I would ‘see’ the answer literally before they had finished asking the question. Some of them became annoyed and thought I was trying to show off, but it was simply the case that I couldn’t help myself from blurting out the answers, since I was so surprised that the answers were so readily available to me.


    Enough of the self-aggrandisement. Suffice to say that long-term use of nootropics can (in my opinion and experience) confer benefits far above and beyond even the not-inconsiderable benefits to be had from intermittent noop use.

    The human brain is a beautiful, fluid, organic learning engine that can truly surprise and amaze. Continuous nootropic use only facilitates this. Try it for yourself.


    9 User Comments

    • Dale

      What were the names of the various nootropics you’ve used and actually worked?

      Posted on Nov 13, 2014 Reply
    • Grody

      What you are experiencing is extra sensory perception. You have trained your brain to tap into the collective unconscious, and now you are gleaning your information organically from that, even though you have never encountered it with your traditional 5 senses. I have learned to do this too, but started my training with a massive head injury followed with psychedelics use. Regardless of how you get to this point, it sure is nice to not have an impenetrable wall around the personal consciousness. It makes life much more rich and enticing… But weird.

      Great site brother. I will definitely try out your two main stacks once I achieve my next finance milestone.

      Posted on Jan 11, 2016 Reply
    • johnwan

      This is great.

      Posted on Sep 12, 2017 Reply
    • Beth

      I’ve heard that either Nootropics or neuro enhancers have wide ranging varying effects on different people. Can anyone tell me what that is due to? Doseage? Concentration? Persons’ own neurobiology? Differing quality of the drug? Whether it is from a natural source or manufactured in a lab?

      Posted on Mar 14, 2018 Reply
      • Mind Nutrition

        All of those are certainly factors, though it will largely depend on someone’s physiology and genetic makeup.

        If one has underlying issues, that can lead to a varied response to some compounds. You may not tolerate caffeine, while someone else enjoys the benefits it can provide.

        There is also the factor of self-awareness, sometimes the effects are not physically perceptible, or they are subtle.

        Extracts are also produced to different strengths and using different processes, so this can all play a role in what sort of effect is achieved. The more popular a compound and the more standardized its production process is, the more likely you are to get a good idea of how that ingredient works on average.

        Posted on Mar 14, 2018 Reply
        • Elizabeth Haran

          Thank you for your clarifications. As some exploring the possibility of creating a healthy nootropic product how would I satisfy my own need to be sure that none of my customers suffers extreme adverse effects from a nootropic due to their own body chemistry where another customer experiences only beneficial results? Is there any way to do that?
          Thank you.

          Posted on Mar 14, 2018 Reply
          • Mind Nutrition

            Healthy individuals won’t suffer extreme adverse effects with over the counter nootropics. Using any other compounds would require experience or expert guidance.

            In general, most people will respond in a similar way to a compound and the few exceptions may have some underlying deficiencies or conditions. As for considering the interactions between compounds within a formula, that comes down to trial-and-error, experience, and research.

            It is the one of the most significant reasons we advise against formulas that include too many ingredients. Anything over 10 or so ingredients is generally crossing that line.

            Posted on Mar 14, 2018 Reply
    • Researcher

      The product links in the article seem to be broken

      Posted on Oct 22, 2018 Reply
      • Mind Nutrition

        Thank you, we’ve fixed them as this article is quite old.

        Posted on Nov 03, 2018 Reply

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